Nah genetic disorders aren’t mutations, they’re incorrect copies of original traits. I’m not a geneticist so don’t quote me on this, but the reason incest causes problems has nothing to do with mutations as they rarely happen and everything to do with not having enough variation in your own genetics to cover when there’s “data loss”. Again, I’m not a scientist.
As everyone has said, lossless compression might not have great ratios, but if it’s still worth it I recommend dwarfs as it creates read only mountable filesystems with minimal setup https://github.com/mhx/dwarfs